| # | Eastern Conference | MP | W | D | L | G | GD | Pts | Form |
|---|---|---|---|---|---|---|---|---|---|
| 1. | Charleston | 5 | 5 | 0 | 0 | 16:3 | 13 | 15 | |
| 2. | Indy Eleven | 5 | 4 | 1 | 0 | 11:4 | 7 | 13 | |
| 3. | Pittsburgh | 5 | 3 | 2 | 0 | 9:4 | 5 | 11 | |
| 4. | Louisville City | 5 | 3 | 1 | 1 | 14:5 | 9 | 10 | |
| 5. | Detroit | 5 | 2 | 2 | 1 | 5:4 | 1 | 8 | |
| 6. | Tampa Bay | 5 | 2 | 1 | 2 | 10:6 | 4 | 7 | |
| 7. | Birmingham | 5 | 2 | 1 | 2 | 4:6 | -2 | 7 | |
| 8. | North Carolina | 5 | 1 | 2 | 2 | 6:6 | 0 | 5 | |
| 9. | Rhode Island | 5 | 1 | 2 | 2 | 6:9 | -3 | 5 | |
| 10. | Loudoun | 5 | 1 | 1 | 3 | 4:7 | -3 | 4 | |
| 11. | Miami FC | 5 | 1 | 0 | 4 | 3:8 | -5 | 3 | |
| 12. | Hartford Athletic | 5 | 0 | 0 | 5 | 2:16 | -14 | 0 | |
| # | Western Conference | MP | W | D | L | G | GD | Pts | Form |
| 1. | Colorado Springs | 5 | 4 | 1 | 0 | 10:2 | 8 | 13 | |
| 2. | New Mexico | 5 | 4 | 0 | 1 | 10:9 | 1 | 12 | |
| 3. | Memphis | 5 | 3 | 1 | 1 | 12:6 | 6 | 10 | |
| 4. | Sacramento Republic | 5 | 2 | 3 | 0 | 9:5 | 4 | 9 | |
| 5. | Phoenix Rising | 5 | 2 | 2 | 1 | 8:6 | 2 | 8 | |
| 6. | San Antonio | 5 | 1 | 3 | 1 | 7:6 | 1 | 6 | |
| 7. | FC Tulsa | 5 | 1 | 2 | 2 | 6:13 | -7 | 5 | |
| 8. | El Paso | 5 | 1 | 1 | 3 | 4:6 | -2 | 4 | |
| 9. | Oakland Roots | 5 | 1 | 1 | 3 | 6:10 | -4 | 4 | |
| 10. | Orange County SC | 5 | 1 | 1 | 3 | 3:7 | -4 | 4 | |
| 11. | Monterey Bay | 5 | 1 | 1 | 3 | 4:9 | -5 | 4 | |
| 12. | Las Vegas Lights | 5 | 0 | 2 | 3 | 5:13 | -8 | 2 |
| # | Eastern Conference | MP | W | D | L | G | GD | Pts | Form |
|---|---|---|---|---|---|---|---|---|---|
| 1. | Charleston | 10 | 8 | 2 | 0 | 26:7 | 19 | 26 | |
| 2. | Louisville City | 9 | 7 | 1 | 1 | 28:9 | 19 | 22 | |
| 3. | Detroit | 8 | 5 | 2 | 1 | 11:7 | 4 | 17 | |
| 4. | Indy Eleven | 10 | 5 | 2 | 3 | 20:17 | 3 | 17 | |
| 5. | Tampa Bay | 10 | 4 | 4 | 2 | 22:12 | 10 | 16 | |
| 6. | Birmingham | 10 | 4 | 2 | 4 | 9:14 | -5 | 14 | |
| 7. | Pittsburgh | 10 | 3 | 4 | 3 | 10:10 | 0 | 13 | |
| 8. | Loudoun | 10 | 3 | 1 | 6 | 11:15 | -4 | 10 | |
| 9. | North Carolina | 10 | 2 | 4 | 4 | 11:13 | -2 | 10 | |
| 10. | Hartford Athletic | 9 | 3 | 0 | 6 | 8:20 | -12 | 9 | |
| 11. | Rhode Island | 10 | 1 | 6 | 3 | 10:16 | -6 | 9 | |
| 12. | Miami FC | 10 | 1 | 1 | 8 | 10:21 | -11 | 4 | |
| # | Western Conference | MP | W | D | L | G | GD | Pts | Form |
| 1. | Sacramento Republic | 10 | 5 | 5 | 0 | 16:8 | 8 | 20 | |
| 2. | New Mexico | 9 | 6 | 1 | 2 | 13:14 | -1 | 19 | |
| 3. | Phoenix Rising | 10 | 4 | 3 | 3 | 13:11 | 2 | 15 | |
| 4. | Orange County SC | 10 | 4 | 3 | 3 | 12:11 | 1 | 15 | |
| 5. | Monterey Bay | 10 | 4 | 2 | 4 | 12:14 | -2 | 14 | |
| 6. | San Antonio | 10 | 3 | 5 | 2 | 15:12 | 3 | 14 | |
| 7. | Memphis | 10 | 4 | 1 | 5 | 16:14 | 2 | 13 | |
| 8. | Colorado Springs | 10 | 4 | 1 | 5 | 11:11 | 0 | 13 | |
| 9. | Las Vegas Lights | 10 | 3 | 2 | 5 | 12:19 | -7 | 11 | |
| 10. | FC Tulsa | 9 | 2 | 4 | 3 | 13:19 | -6 | 10 | |
| 11. | Oakland Roots | 10 | 2 | 2 | 6 | 10:18 | -8 | 8 | |
| 12. | El Paso | 10 | 1 | 2 | 7 | 9:15 | -6 | 5 |
| # | Eastern Conference | MP | W | D | L | G | GD | Pts | Form |
|---|---|---|---|---|---|---|---|---|---|
| 1. | Charleston | 11 | 8 | 3 | 0 | 26:7 | 19 | 27 | |
| 2. | Louisville City | 9 | 7 | 1 | 1 | 28:9 | 19 | 22 | |
| 3. | Detroit | 8 | 5 | 2 | 1 | 11:7 | 4 | 17 | |
| 4. | Indy Eleven | 11 | 5 | 2 | 4 | 21:19 | 2 | 17 | |
| 5. | Tampa Bay | 10 | 4 | 4 | 2 | 22:12 | 10 | 16 | |
| 6. | Birmingham | 10 | 4 | 2 | 4 | 9:14 | -5 | 14 | |
| 7. | Pittsburgh | 10 | 3 | 4 | 3 | 10:10 | 0 | 13 | |
| 8. | Loudoun | 11 | 3 | 2 | 6 | 13:17 | -4 | 11 | |
| 9. | North Carolina | 11 | 2 | 5 | 4 | 11:13 | -2 | 11 | |
| 10. | Hartford Athletic | 9 | 3 | 0 | 6 | 8:20 | -12 | 9 | |
| 11. | Rhode Island | 10 | 1 | 6 | 3 | 10:16 | -6 | 9 | |
| 12. | Miami FC | 11 | 2 | 1 | 8 | 12:21 | -9 | 7 | |
| # | Western Conference | MP | W | D | L | G | GD | Pts | Form |
| 1. | Sacramento Republic | 10 | 5 | 5 | 0 | 16:8 | 8 | 20 | |
| 2. | New Mexico | 9 | 6 | 1 | 2 | 13:14 | -1 | 19 | |
| 3. | Phoenix Rising | 11 | 4 | 3 | 4 | 13:12 | 1 | 15 | |
| 4. | Orange County SC | 10 | 4 | 3 | 3 | 12:11 | 1 | 15 | |
| 5. | Monterey Bay | 11 | 4 | 3 | 4 | 13:15 | -2 | 15 | |
| 6. | San Antonio | 10 | 3 | 5 | 2 | 15:12 | 3 | 14 | |
| 7. | Memphis | 10 | 4 | 1 | 5 | 16:14 | 2 | 13 | |
| 8. | Colorado Springs | 10 | 4 | 1 | 5 | 11:11 | 0 | 13 | |
| 9. | Oakland Roots | 11 | 3 | 2 | 6 | 12:19 | -7 | 11 | |
| 10. | Las Vegas Lights | 11 | 3 | 2 | 6 | 13:21 | -8 | 11 | |
| 11. | FC Tulsa | 9 | 2 | 4 | 3 | 13:19 | -6 | 10 | |
| 12. | El Paso | 11 | 1 | 2 | 8 | 9:16 | -7 | 5 |